Allophenylnorstatine, acting as a transition state mimic, is a building block for HIV-1 protease inhibitors.
The β-amino acid is a stereoisomer of the phenylnorstatine component of bestatin, apstatin and further aminopeptidase inhibitors.
F-4220
Allophenylnorstatine
(2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid
Synonym:
Apns
| C10H13NO3 | Mr: 195.22 | [62084-21-3] |
| Longterm storage temperature: | -20 ± 5 °C | C10H13NO3 |
Literature:
S.Kageyama et al., Antimicrob. Agents Chemother., 37, 810 (1993)
K.Yoshimura et al., Proc. Natl. Acad. Sci. USA, 96, 8675 (1999)
S.Nakatani et al., J. Med. Chem., 51, 2992 (2008)
S.Kageyama et al., Antimicrob. Agents Chemother., 37, 810 (1993)
K.Yoshimura et al., Proc. Natl. Acad. Sci. USA, 96, 8675 (1999)
S.Nakatani et al., J. Med. Chem., 51, 2992 (2008)
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