Synaptobrevin-2 Fragments

The tetanus and botulinum B toxins block neurotransmitter release by cleaving the synaptic vesicle protein synaptobrevin-2. Two peptides containing this cleavage site have been shown to inhibit the in vitro proteolysis of synaptobrevin-2 by both toxins.

Family Literatur:
G.Schiavo et al., Nature, 359, 832 (1992)