Stichodactyla helianthus Neurotoxins

These monosubstituted analogs of ShK toxin, a class of K channel blocking peptide toxins derived from the sea anemone Stichodactyla helianthus, were prepared in order to identify functionally important residues. Hereby it has been shown that the location of Lys22 within a helical structure represents a unique difference between the interactive surfaces of the sea anemone and scorpion toxins.

Family Literatur:
M.W.Pennington et al., Biochem. Biophys. Res. Commun., 219, 696 (1996)
J.E.Tudor et al., Nat. Struct. Biol., 3, 317 (1996)