Prolyl Endopeptidase (PEP) Inhibitors and Substrates

PEP, a serine protease of unusual specificity cleaving the sequenceX-Pro-Y (where X and Y are any amino acids) on the carboxyl side of proline, is also called prolyl oligopeptidase (POP).

A-2860	Boc-Asn-Phe-Pro-aldehyde
L-2090	Suc-Ala-Pro-pNA
I-1345	Suc-Gly-Pro-AMC
J-1095	Z-Ala-Pro-4MβNA
L-1215	Z-Ala-Pro-pNA
K-1570	Z-Gly-Ala-Pro-βNA
I-1145	Z-Gly-Pro-AMC
J-1365	Z-Gly-Pro-4MβNA
K-1190	Z-Gly-Pro-βNA
L-1235	Z-Gly-Pro-pNA
C-1890	Z-Gly-Pro-Ala-OH
M-1265	Z-Gly-Pro-Leu-Gly-Pro-OH
J-1135	Z-Lys-Pro-4MβNA
N-1490	Z-Pro-Pro-aldehyde-dimethyl acetal