H-6286
(Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human)
H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2
Trifluoroacetate salt
Synonym:
FSLLRYamide, (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) amide (mouse), (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) amide (human), (Phe1,Ser2,Tyr6)-Thrombin Receptor (1-6) amide (human)
| C39H60N10O8 | Mr: 796.97 | [245329-02-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C39H60N10O8 |
PAR-2 antagonist. FSLLRY-NH2 inhibited activation of PAR-2 by trypsin in PAR-2 receptor expressing KNRK cells. Half-maximal inhibition of calcium signaling was observed at about 50 µM. In contrast, the activation of PAR-2 by SLIGRL-NH2 (PAR-2 (1-6) amide (mouse, rat) (H-5078)) was not inhibited by FSLLRY-NH2.
Literature:
B.Al-Ani et al., J. Pharmacol. Exp. Ther., 300, 702 (2002)
S.Wilson et al., Biochem. J., 388, 967 (2005)
B.Al-Ani et al., J. Pharmacol. Exp. Ther., 300, 702 (2002)
S.Wilson et al., Biochem. J., 388, 967 (2005)
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Family Description:
For further PAR-1 peptides see the product family Thrombin Receptor-Derived Peptides.
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