H-9210
(Des-Gly10,D-His(Bzl)6,Pro-NHEt9)-LHRH
Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt
Acetate salt
Also available as cGMP API.
Synonym:
Histrelin
| C66H86N18O12 | Mr: 1323.52 | [220810-26-4] net |
| Longterm storage temperature: | -20 ± 5 °C | C66H86N18O12 |
As a potent LHRH agonist, Histrelin stimulates LH and FSH release and inhibits the actions of sex steroids on the male and female reproductive tracts. Its potency in vivo and in vitro is similar to that of the D-Trp6-containing analog. Especially because of its high water solubility and greater lipophilic character, it appears promising for clinical application.
Literature:
K.Sundaram et al., Life Sci., 28, 83 (1981)
J.DeFazio et al., Endocr. Res., 10, 163 (1984)
M.J.Gibson and D.S.Kohtz, Contraception, 31, 91 (1985)
M.J.Karten and J.E.Rivier, Endocr. Rev., 7, 44 (1986)
G.C.Doelle et al., Horm. Metab. Res., 18, 201 (1986)
J.W.Gunnet et al., J. Endocrinol., 131, 211 (1991)
M.Montagner et al., Reprod. Fertil. Dev., 17, 222 (2005)
Merck Index, 14th ed., No. 4722, (2006)
K.Sundaram et al., Life Sci., 28, 83 (1981)
J.DeFazio et al., Endocr. Res., 10, 163 (1984)
M.J.Gibson and D.S.Kohtz, Contraception, 31, 91 (1985)
M.J.Karten and J.E.Rivier, Endocr. Rev., 7, 44 (1986)
G.C.Doelle et al., Horm. Metab. Res., 18, 201 (1986)
J.W.Gunnet et al., J. Endocrinol., 131, 211 (1991)
M.Montagner et al., Reprod. Fertil. Dev., 17, 222 (2005)
Merck Index, 14th ed., No. 4722, (2006)
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Family Description:
H-9210 corresponds to histrelin
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