H-4116
(Des-Gly10,D-Trp6,Pro-NHEt9)-LHRH High acetate salt
Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt High acetate salt
Also available as cGMP API.
Synonym:
Deslorelin High acetate salt
| C64H83N17O12 | Mr: 1282.47 | [57773-65-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C64H83N17O12 |
Short-term administration of deslorelin stimulates the formation of LH and FSH, which induce an increase in the production of testosterone and estradiol. Prolonged administration of the GnRH agonist causes a sustained down-regulation of circulating LH and FSH levels and hence suppression of steroidogenesis.
Literature:
D.H.Coy et al., J. Med. Chem., 19, 423 (1976)
K.Sundaram et al., Life Sci., 28, 83 (1981)
B.Candas et al., J. Clin. Endocrinol. Metab., 70, 1046 (1990)
P.P.Feuillon et al., J. Endocrinol. Invest., 24, 734 (2001)
Merck Index, 14th ed., No. 2923, (2006)
D.H.Coy et al., J. Med. Chem., 19, 423 (1976)
K.Sundaram et al., Life Sci., 28, 83 (1981)
B.Candas et al., J. Clin. Endocrinol. Metab., 70, 1046 (1990)
P.P.Feuillon et al., J. Endocrinol. Invest., 24, 734 (2001)
Merck Index, 14th ed., No. 2923, (2006)
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Family Description:
H-4116 corresponds to deslorelin (high acetate).
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