Hirudin Fragments and Analogs

These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.

Family Literatur:
J.Dodt et al., FEBS Lett., 165, 180 (1984)
J.L.Krstenansky and S.J.T.Mao, FEBS Lett., 211, 10 (1987)
J.M.Maraganore et al., J. Biol. Chem., 264, 8692 (1989)
M.C.Naski et al., J. Biol. Chem., 265, 13484 (1990)