Highly specific and reversible direct thrombin inhibitor.
This product is offered and sold solely for uses reasonably related to the development and submission of information under a Federal law which regulates the manufacture, use or sale of drugs (the “Bolar Exemption”). Bachem cannot be made liable for any infringement of intellectual property rights. It is the sole and only responsibility of the purchaser or user of this product to comply with the relevant national rules and regulations.
H-6668
Bivalirudin
H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
Trifluoroacetate salt
Synonym:
BG 8967, Hirulog, Hirulog I
| C98H138N24O33 | Mr: 2180.32 | [128270-60-0] net |
| Longterm storage temperature: | -20 ± 5 °C | C98H138N24O33 |
Literature:
T.E.Warkentin et al., Thromb. Haemost., 99, 830 (2008)
T.E.Warkentin et al., Thromb. Haemost., 99, 830 (2008)
|
Family Description:
These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.
Family Literature:
J.Dodt et al., FEBS Lett., 165, 180 (1984)
J.L.Krstenansky and S.J.T.Mao, FEBS Lett., 211, 10 (1987)
J.M.Maraganore et al., J. Biol. Chem., 264, 8692 (1989)
M.C.Naski et al., J. Biol. Chem., 265, 13484 (1990)
Print