H-4982
Galanin-Like Peptide (porcine)
H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
Trifluoroacetate salt
Synonym:
GALP (porcine)
| C281H443N81O78 | Mr: 6204.11 | [245114-96-9] net |
| Longterm storage temperature: | -20 ± 5 °C | C281H443N81O78 |
This member of the galanin family has been isolated from porcine hypothalamus. It is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) portion of galanin. Receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2; IC50 = 0.24 nM) and a lower affinity for the GALR1 receptor (IC50 = 4.3 nM). GALP is therefore an endogenous ligand that preferentially binds the GALR2 receptor, whereas galanin is relatively non-selective.
Literature:
T.Ohtaki et al., J. Biol. Chem., 274, 37041 (1999)
J.A.Larm and A.L.Gundlach, Neuroendocrinology, 72, 67 (2000)
A.Jureus et al., Endocrinology, 141, 2703 (2000)
A.Seth et al., Neuroendocrinology, 77, 125 (2003)
T.Ohtaki et al., J. Biol. Chem., 274, 37041 (1999)
J.A.Larm and A.L.Gundlach, Neuroendocrinology, 72, 67 (2000)
A.Jureus et al., Endocrinology, 141, 2703 (2000)
A.Seth et al., Neuroendocrinology, 77, 125 (2003)
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