Brain Natriuretic Peptides (BNP)

BNP, originally isolated from porcine brain, belongs to the class of natriuretic peptides, having an amino acid sequence and a pharmacological activity spectrum (including diuretic-natriuretic, hypotensive, and vasorelaxant actions) remarkably similar to that of atrial natriuretic peptide (ANP). Meanwhile, BNP precursor molecules have also been shown to exist in human and rat cardiac tissue. Comparison of the precursor sequences demonstrates structural species differences between the mammalian BNPs, a finding which contrasts with the highly conserved ANP sequences.

Family Literatur:
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M.Aburaya et al., Biochem. Biophys. Res. Commun., 163, 226 (1989)
T.Sudoh et al., Biochem. Biophys. Res. Commun., 159, 1427 (1989)
S.-I.Suga et al., Endocrinology, 130, 229 (1992)

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