H-2095
Atrial Natriuretic Factor (1-28) (human)
H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
(Disulfide bond)
Synonym:
αhANF, Carperitide
| C127H203N45O39S3 | Mr: 3080.49 | [89213-87-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C127H203N45O39S3 |
ANP/ANF is synthesized in cardiac myocytes and is primarily released in response to atrial wall stretching and intravascular volume expansion. The peptide signals via the guanylate cyclase-linked natriuretic peptide receptor A (NPR-A) and plays an important role in blood pressure regulation and blood volume homeostasis. ANP/ANF exerts vasodilatory, diuretic, natriuretic, anti-inflammatory, antifibrotic and antimitogenic effects. As BNP, ANP stimulates lipoylsis in adipocytes.
Literature:
C.Sengenes et al., FASEB J., 14, 1345 (2000)
S.Mukaddam-Daher, Expert Opin. Ther. Targets, 10, 239 (2006)
G.M.Felker et al., CMAJ, 175, 611 (2006)
S.Rubattu et al., Am. J. Hypertens., 21, 733 (2008)
C.Sengenes et al., FASEB J., 14, 1345 (2000)
S.Mukaddam-Daher, Expert Opin. Ther. Targets, 10, 239 (2006)
G.M.Felker et al., CMAJ, 175, 611 (2006)
S.Rubattu et al., Am. J. Hypertens., 21, 733 (2008)
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