H-4566
Apelin-13 (human, bovine, mouse, rat)
H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
| C69H111N23O16S | Mr: 1550.85 | [217082-58-1] |
| Longterm storage temperature: | -20 ± 5 °C | C69H111N23O16S |
Endogenous peptide ligand for the human APJ receptor, a putative receptor protein related to the angiotensin receptor (AT1). This peptide exerted an acidification-rate-promoting activity in the CHO cells expressing the APJ receptor with a median effective concentration (EC50) value of 0.37 nM. In a study of Valle et al. chronic central administration of apelin-13 over 10 days increased food intake, body weight, locomotor activity and body temperature in C57BL/6 mice.
Literature:
K.Tatemoto et al., Biochem. Biophys. Res. Commun., 251, 471 (1998)
A.Valle et al., J. Neuroendocrinol., 20, 79 (2008)
K.Tatemoto et al., Biochem. Biophys. Res. Commun., 251, 471 (1998)
A.Valle et al., J. Neuroendocrinol., 20, 79 (2008)
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