Adrenomedullin (AM) elicits a potent and longlasting hypotensive effect and is considered as a hormone involved in blood pressure control. Additionally, AM acts as a protective factor of blood vessels.
Adrenomedullin is a potent stimulator of osteoblastic activity. Further biological activities of AM include reduction of oxidative stress and inhibition of endothelial cell apoptosis.
H-2932
Adrenomedullin (human)
H-Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
(Disulfide bond)
Trifluoroacetate salt
| C264H406N80O77S3 | Mr: 6028.82 | [148498-78-6] |
| Longterm storage temperature: | -20 ± 5 °C | C264H406N80O77S3 |
Literature:
K.Kitamura et al., Biochem. Biophys. Res. Commun., 192, 553 (1993)
J.Cornish et aal., Am. J. Physiol., 273, E1113 (1997)
J.P.Hinson et al., Endocr. Rev., 21, 138 (2000)
J.Kato et al., Arterioscler. Thromb. Vasc. Biol., 25, 2480 (2005)
E.Zudaire et al., J. Leukoc. Biol., 80, 237 (2006)
K.Kitamura et al., Biochem. Biophys. Res. Commun., 192, 553 (1993)
J.Cornish et aal., Am. J. Physiol., 273, E1113 (1997)
J.P.Hinson et al., Endocr. Rev., 21, 138 (2000)
J.Kato et al., Arterioscler. Thromb. Vasc. Biol., 25, 2480 (2005)
E.Zudaire et al., J. Leukoc. Biol., 80, 237 (2006)
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