Q-2695
Antazoline · H3PO4
2-(N-Phenyl-N-benzyl-aminomethyl)-imidazoline · H3PO4
Also available as cGMP API.
Synonym:
Benzyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl-amine · H3PO4
| C17H19N3 · H3PO4 | Mr: 363.35 | [154-68-7] |
| Longterm storage temperature: | +5 ± 3 °C | C17H19N3 · H3PO4 |
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Family Description:
Antazoline, an imidazoline derivative with antihistaminic properties, has been shown to exert neuroprotection against hypoxia and NMDA toxicity in cerebellar and striatal neuronal cultures through a voltage-dependent blockade of glutamatergic NMDA receptors. Recently, an additional neuroprotective mechanism which functions by decreasing the release of glutamate through inhibition of presynaptic Ca2+-channels has been proposed.
Family Literature:
D.Berdeu et al., Eur. J. Pharmacol., 324, 233 (1997)
G.Olmos et al., Br. J. Pharmacol., 127, 1317 (1999)
D.Milhaud et al., Neuropharmacology, 39, 2244 (2000)
D.Milhaud et al., NeuroReport, 13, 1711 (2002)
D.Milhaud et al., Neuroscience, 120, 475 (2003)
M.Swiader et al., Eur. Neuropsychopharmacol., 14, 307 (2004)
B.Hemmateenejad et al., Talanta, 68, 1222 (2006)
E.Souri et al., Chem. Pharm. Bull., 54, 119 (2006)
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