CD163

Clones 5C6-FAT, RM3/1 and Ki-M8 recognize different epitopes of the human CD163 molecule (scavenger receptor, cysteine rich or SRCR). CD163 is a membrane glycoprotein on monocytes and macrophages which is expressed in the intermediate and late phase of inflammation. The antigen is a member of the scavenger receptor family which is significantly up-regulated by glucocorticoids while it is down-regulated by cyclosporin A and by phorbol esters. An important function of CD163 seems to be in the adhesion of monocytes to activated endothelial cells. CD163-positive cells include skin histiocytes, Kupffer cells, spleen macrophages of the red pulp, and some thymus macrophages. The antigen is found abundantly in human term placenta, and regularly in acute and chronic inflammatory lesions. The antibodies are useful for macrophage phenotyping, for the classification of inflammatory stages in tissue sections and smears (together with 27E10, 25F9 and G16/1), for the characterization of tumorous tissues, and the monitoring of macrophage cell cultures.

Family Literatur:
G.Zwadlo et al., Expl. Cell Biol., 55, 295 (1987)
B.Mues et al., Immunology, 67, 303 (1989)
P.Högger et al., J. Immunol., 161, 1883 (1998)

T-1012	CD163 (human) - Clone Ki-M8
T-1060	CD163 (human) - Clone 5C6-FAT
T-1063	CD163 (human) - Clone 5C6-FAT Azide- and BSA-free
T-1061	CD163 (human) - Clone 5C6-FAT Biotinylated
T-1062	CD163 (human) - Clone 5C6-FAT FITC labeled
T-1072	CD163 (human) - Clone 5C6-FAT R-Phycoerythrin labeled
T-1013	CD163 (human) - Clone RM3/1
T-1014	CD163 (human) - Clone RM3/1 Biotinylated
S-1015	CD163 (human) - ELISA
T-1527	CD163 (human) - Polyclonal
T-1514	CD163 (human, porcine) - Polyclonal