CD120a,b

TNF induces trimerization of TNF-receptor p55 (CD120a) and TNF-receptor p75 (CD120b), thereby eliciting a wide range of responses. These include fever, shock, tissue injury, tumor necrosis, anorexia, induction of other cytokines and immunoregulatory molecules, cell proliferation, differentiation, and apoptosis. htr 9 and utr 1 recognizes the human CD120a and CD120b molecules, respectively. They are useful for studying the effects of TNF-receptor p55 and p75, respectively, in vitro. They inhibit the binding of radiolabeled TNF to human cells expressing the respective TNF receptor. The antibodies may have an agonistic effect in assays measuring cytotoxicity, fibroblast growth or IL-6 secretion.

Family Literatur:
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M.Brockhaus et al., Proc. Natl. Acad. Sci. USA, 87, 3127 (1990)
H.Hohmann et al., J. Biol. Chem., 265, 22409 (1990)