H-7226
Cyclo(-Arg-Gly-Asp-D-Phe-Cys)
Acetate salt
Synonym:
Cyclo(-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide, c(RGDfC)
| C24H34N8O7S | Mr: 578.65 | [862772-11-0] net |
| Longterm storage temperature: | -20 ± 5 °C | C24H34N8O7S |
A RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RGDfC) can be easily conjugated to drugs as combretastatin or surfaces. For the control peptide c(RADfC) see H-7232
Literature:
C.R.Pattillo et al., Pharm. Res., 22, 1117 (2005)
R.Nallamothu et al., AAPS PharmSciTech, 7, E32 (2006)
O.Prante et al., Bioconjugate Chem., 18, 254 (2007)
M.D.Stachler et al., Mol. Ther., 16, 1467 (2008)
K.Marko et al., Bioconjugate Chem., 19, 1757 (2008)
X.Yang et al., Biomaterials, 32, 4151 (2011)
C.R.Pattillo et al., Pharm. Res., 22, 1117 (2005)
R.Nallamothu et al., AAPS PharmSciTech, 7, E32 (2006)
O.Prante et al., Bioconjugate Chem., 18, 254 (2007)
M.D.Stachler et al., Mol. Ther., 16, 1467 (2008)
K.Marko et al., Bioconjugate Chem., 19, 1757 (2008)
X.Yang et al., Biomaterials, 32, 4151 (2011)
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Family Description:
Bachem offers the corresponding control peptides for commonly used RGD-containing sequences:
AcDRGDS (H-3528), control AcDRLDS (H-3534)
DRGDS (H-3532), control DRLDS (H-3536)
RGDS (H-1155), control RGES (H-7745) or SDGRG (H-7740)
c(RGDfC) (H-7226), control c(RADfC) (H-7232)
c(RGDfK) (H-7326), control c(RADfK) (H-7328)
c(RGDfV) (H-2574), control c(RADfV) (H-4088)
GRGDSP (H-7630), control GRADSP (H-6048) or GRGESP (H-3136)
GRGDSPK (H-6190), control GRADSPK (H-5690)
GRGDS (H-1345), control GRGES (H-3166), GRDGS (H-3172), or SDGRG (H-7740)
GRGDTP (H-7725), control GRGETP (H-3752).
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