Building block for Staudinger ligation as well as for "click chemistry". This highly selective reaction can be applied for the conjugation of peptides with various molecules and for the cyclization of peptides.
The azido moiety may also be considered as a protected amino group which is deblocked under reductive conditions.
Q-2740
6-Azido-hexanoic acid
Synonym:
ε-Azidocaproic acid
| C6H11N3O2 | Mr: 157.17 | [79598-53-1] |
| Longterm storage temperature: | -20 ± 5 °C | C6H11N3O2 |
Literature:
P.Wu et al., Angew. Chem. Int. Ed. Engl., 43, 3928 (2004)
C.Grandjean et al., J. Org. Chem., 70, 7123 (2005)
A.Watzke et al., Bioorg. Med. Chem., 14, 6288 (2006)
A.Vila et al., Chem. Res. Toxicol., 21, 432 (2008)
C.-B.Yim et al., Bioconjugate Chem., 20, 1323 (2009)
P.Wu et al., Angew. Chem. Int. Ed. Engl., 43, 3928 (2004)
C.Grandjean et al., J. Org. Chem., 70, 7123 (2005)
A.Watzke et al., Bioorg. Med. Chem., 14, 6288 (2006)
A.Vila et al., Chem. Res. Toxicol., 21, 432 (2008)
C.-B.Yim et al., Bioconjugate Chem., 20, 1323 (2009)
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Family Description:
Buiding blocks for "click chemistry". See also the product family "Propargylglycine" and the subfamily "p-Azidophenylalanine".
Bachem additionally offers azido derivatives for SPPS: Fmoc-Dab(N2)-OH (B-4145), Fmoc-Orn(N2)-OH (B-4140), Fmoc-Lys(N2)-OH (B-4135), Boc-Orn(N2)-OH · DCHA (A-4770), and Boc-Lys(N2)-OH · DCHA (A-4765).
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