B-2315
Fmoc-Pen(Trt)-OH
Synonym:
Fmoc-β,β-dimethyl-Cys(Trt)-OH
| C39H35NO4S | Mr: 613.78 | [201531-88-6] |
| Longterm storage temperature: | -20 ± 5 °C | C39H35NO4S |
The coupling of peptide thioesters to N-terminal penicillamine followed by desulfuration yielding valine, which was described by Haase et al., broadens the scope of native chemical ligation.
Literature:
S.Lindman et al., Bioorg. Med. Chem., 11, 2974 (2003)
C.Haase et al., Angew. Chem. Int. Ed. Engl., 47, 6807 (2008)
K.Görner et al., J. Org. Chem., 75, 1811 (2010)
S.Lindman et al., Bioorg. Med. Chem., 11, 2974 (2003)
C.Haase et al., Angew. Chem. Int. Ed. Engl., 47, 6807 (2008)
K.Görner et al., J. Org. Chem., 75, 1811 (2010)
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Family Description:
Corresponds to β,β-dimethylcysteine or β-mercaptovaline. For an S-protected derivative of deamino-penicillamine please see Q-1610.
The rigidity of disulfide bridges can be increased by replacing Cys by Pen. Pen analogs of enkephalins, RGD-peptides, urotensin and further active peptides with improved potency and/or selectivity have been described.
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