Phenylacetamidomethyl-Resin (PAM-resin)-Linked Boc-Amino Acids
Resins based on polystyrene-divinylbenzene 1%.
The ester bond between the C-terminal amino acid and Merrifield resin turned out to be not sufficiently stable towards the repetitive treatments with TFA during the Boc-SPPS of long peptides. To avoid such losses the phenylacetamido (PAM) handle has been developed to create a more acid-stable peptide-resin linkage. Cleavage is normally effected by treatment with HF.
Family Literatur:
A.R.Mitchell et al., J. Org. Chem., 43, 2845 (1978)
J.P.Tam et al., Synthesis, 955 (1979)
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