NAC induced apoptosis in rat and human smooth muscle cells and serves as an efficient substrate for the rat liver microsomal glutathione transferase with 1-chloro-2,4-dinitrobenzene as second substrate. The conjugate with phenethyl isothiocyanate induces apoptosis predominantly in growth-promoted cells, which leads to the assumption that this conjugate inhibits lung carcinogenesis. Furthermore, NAC has been found to act as a specific inhibitor of TGF-β signaling targeting different components of the TGF-β signaling machinery.
Bachem also offers the dimer of NAC, DiNAC (E-2965).
E-3710
Ac-Cys-OH
Also available as cGMP API.
Synonym:
NAC
| C5H9NO3S | Mr: 163.20 | [616-91-1] |
| Longterm storage temperature: | RT | C5H9NO3S |
Literature:
R.Weinander et al., J. Biol. Chem., 269, 71 (1994)
J.-C.Tsai et al., J. Biol. Chem., 271, 3667 (1996)
M.Morini et al., Int. J. Biol. Markers, 14, 268 (1999)
Y.M.Yang et al., Cancer Res., 65, 8538 (2005)
S.K.Meurer et al., Biochem. Pharmacol., 70, 1026 (2005)
Merck Index, 14th ed., No. 88, (2006)
R.Weinander et al., J. Biol. Chem., 269, 71 (1994)
J.-C.Tsai et al., J. Biol. Chem., 271, 3667 (1996)
M.Morini et al., Int. J. Biol. Markers, 14, 268 (1999)
Y.M.Yang et al., Cancer Res., 65, 8538 (2005)
S.K.Meurer et al., Biochem. Pharmacol., 70, 1026 (2005)
Merck Index, 14th ed., No. 88, (2006)
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