α-Amino Thiono Acid Derivatives

Activated building blocks for the synthesis of thioxopeptides. In the presence of the acid-labile thioamide (psi[CS-NH]) moiety, the Boc group can be removed with SnCl4 in organic solvents.

Family Literatur:
R.Frank and M.Schutkowski, Chem. Commun., 2509 (1996)
M.A.Shalaby et al., J. Org. Chem., 61, 9045 (1996)
R.Frank et al., Angew. Chem. Int. Ed. Engl., 39, 1120 (2000)