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BIBP3226 trifluoroacetate salt
Diphenylacetyl-D-Arg-4-hydroxybenzylamide trifluoroacetate salt

E-3620

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
E-3620.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 155.00
CHF 144.15 (7%)
E-3620.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 618.00
CHF 574.74 (7%)
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Details

The Y₁ receptor antagonist BIBP-3226, a derivative of D-arginine, binds to the Y₁ receptor with high affinity (its Ki was 7 nM versus the Ki of 0.2 nM for NPY). BIBP3226 also reduced the NPY-induced increase in intracellular calcium as well as the pressor response in vitro and in vivo. BIBP3226 inhibited NPY induced feeding in rats. In dogs, intra-arterial infusion of BIBP-3226 interrupted tonic NPY Y1 receptor-mediated vasoconstriction in exercising skeletal muscle, resulting in substantial increases in experimental limb blood flow.
CAS-Number (trifluoroacetate): 1068148-47-9.
Item Number 4034548
APC Number 60-1-22
Synonyms BIBP 3226
Molecular Formula C₂₇H₃₁N₅O₃
Relative Molecular Mass 473.58
CAS Registry Number [159013-54-4] net
Source Synthetic
Storage Conditions -20 ± 5 °C