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Availability: In stock

DL-2,3-Isopropylideneglycerylmethyl resin (200-400 mesh, 0.8-1.1 mmol/g)

D-2240

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-2240.0001 1 g Ships within 3-5 business days  
CHF 175.00
CHF 162.75 (7%)
D-2240.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 711.00
CHF 661.23 (7%)
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Details

This glycerine-derived "polymeric ketal" can be turned into a polymeric 1,2-diol by acid-catalyzed aqueous cleavage or transketalation with ethylene glycol (C.C.Leznoff and J.Y.Wong). Both polymer derivatives can be reacted with carbonyl compounds. So Fmoc-amino aldehydes and acetals (e.g. Fmoc-NHCH₂CH(OCH₃)₂) bound to this resin yield, after routine Fmoc/tBu SPPS and acid-catalyzed cleavage, useful peptide derivatives, e.g. for ligation. Hirose et al. obtained the chitinase inhibitor argadin containing an Asp β-aldehyde residue via Fmoc-SPPS employing acetalization to the liberated resin-bound glycerine.
Item Number 4027174
Substitution 0.8-1.1 mmol/g
Storage Conditions +5 ± 3 °C

Product citations

S.Chamoin et al., Tetrahedron Lett., 39, 4179 (1998)
C.C.Leznoff and J.Y.Wong, Can. J. Chem., 51, 3756 (1973)