Shopping Cart - CHF 0.00

You have no items in your shopping cart.

Return to Previous Page

Availability: In stock

Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g)

D-2230

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-2230.0001 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 216.00
CHF 200.88 (7%)
D-2230.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 855.00
CHF 795.15 (7%)
Add to Wish List
Add to Compare

Details

Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of β-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane.
Fmoc-α-amino alcohols can be anchored to PDDM in the presence of BF₃ etherate. As the resulting benzhydryl ethers can be cleaved with 1% TFA/DCM, fully protected peptide alcohols can be obtained.
Item Number 4027172
Synonyms PDDM resin, Ph-CN₂-Ph-polymer
Substitution 0.7-1.3 mmol/g
Storage Conditions -20 ± 5 °C

Product citations

M.Mergler et al., Tetrahedron Lett., 40, 4663 (1999)
M.Mergler and F.Dick, Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 5th International Symposium, London, p. 351, R.Epton, ed., Mayflower Scientific, (1998)
Ger. Offen. 2436722, (1975)
P.H.Chapman and D.Walker, J. Chem. Soc. Chem. Commun., 690 (1975)