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Availability: In stock

Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh, 0.3-0.6 mmol/g)
Fmoc-Cys(2-methoxy-4-alkoxybenzyl alcohol resin)-OH

D-2170

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-2170.0001 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 200.00
CHF 186.00 (7%)
D-2170.0005 5 g Ships within 3-5 business days  
CHF 777.00
CHF 722.61 (7%)
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Details

This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRIN™-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (and, if desired, standard Fmoc-SPPS) lthe modified cysteine derivative can be cleaved with TFA/water/triisopropylsilane (94:4:2, v/v/v) from the SASRIN™-resin. Extending the peptide chain at the C-terminus can be achieved by activation of the side-chain linked cysteine carboxylic acid and coupling to additional amino acids.
Cys linked to a resin by its thiol function was oxidized with MCPBA after esterification and Nα-modification (Yamada et al.). DBU-induced elimination yielded dehydroalanine derivatives.
Item Number 4026902
Substitution 0.3-0.6 mmol/g
Storage Conditions +5 ± 3 °C

Product citations

M.Yamada et al., Tetrahedron Lett., 39, 289 (1998)
N.G.J.Delaet and T.Tsuchida, Lett. Pept. Sci., 2, 325 (1995)