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Availability: In stock

2-Chlorotrityl chloride resin (200-400 mesh, 1.00-2.50 mmol/g)

D-1965

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-1965.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 144.00
CHF 133.92 (7%)
D-1965.0025 25 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 577.00
CHF 536.61 (7%)
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Details

A very acid sensitive resin suitable for the synthesis of protected peptide fragments by the Fmoc-strategy. ClTrt resin is in particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides (please see 2-Chlorotrityl Chloride Resin-Linked Amino Acids). Release from this resin is achieved by using 1-50 % TFA in CH₂Cl₂ containing 8 % triisopropylsilane, AcOH/CF₃CH₂OH/CH₂Cl₂, 0.5 % TFA or hexafluoroisopropanol/CH₂Cl₂. ClTrt resin has been used in cyclization reactions under Heck reaction conditions, the solid phase synthesis of β-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones and in Mannich reactions of alkynes, secondary amines and aldehydes in the presence of a copper (I) salt affording the corresponding aminomethylalkynyl adducts.
2-Chlorotrityl resin is highly suitable for the synthesis of peptide alcohols, e.g., peptaibols, and peptide ω-aminoalkylamides.
Item Number 4025425
Synonyms 2-ClTrt resin, 2-CTC resin
Substitution 1.00-2.50 mmol/g
Storage Conditions -20 ± 5 °C

Product citations

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K.Barlos et al., Tetrahedron Lett., 30, 3943 (1989)
K.Barlos et al., Tetrahedron Lett., 30, 3947 (1989)