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Availability: In stock

Fmoc-Pro-DHPP resin (200-400 mesh, 0.4-0.7 mmol/g)

D-1830

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-1830.0001 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 144.00
CHF 133.92 (7%)
D-1830.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 567.00
CHF 527.31 (7%)
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Details

DHPP-resin, i.e. 4-(1',1'-dimethyl-1'-hydroxypropyl)phenoxyacetyl-alanyl-aminomethyl resin, has been developed especially for the synthesis of peptides containing a C-terminal proline. The bulkiness of the linker prevents diketopiperazine formation. As the esterification of Fmoc-Pro-OH (yielding a modified t-butyl ester) is impeded as well, the resin is offered as loaded derivative. Peptides can be cleaved from this resin applying the standard protocols for the cleavage from Wang resin.
Fmoc-Pro-DHPP-resin is an alternative to H-Pro-ClTrt-resin (D-2000) not only if an increased acid stability is required. The resin is more polar than 2-chlorotrityl resin and the Pro residue is more accessible.
Item Number 4019306
Substitution 0.4-0.7 mmol/g
Storage Conditions +5 ± 3 °C

Product citations

F.Dick and M.Schwaller, Peptides 1994, Proceedings of the 23rd European Peptide Symposium, Braga/Portugal, p. 240, H.L.S.Maya, ed., Escom, Leiden, (1995)
J.Kochansky and R.M.Wagner, Tetrahedron Lett., 33, 8007 (1992)
K.Akaji et al., J. Chem. Soc. Chem. Commun., 24, 584 (1990)