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Availability: In stock

SASRIN™ resin (200-400 mesh, 0.80-1.20 mmol/g)
2-Methoxy-4-alkoxybenzyl alcohol resin

D-1295

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-1295.0001 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 113.00
CHF 105.09 (7%)
D-1295.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 433.00
CHF 402.69 (7%)
D-1295.0025 25 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'730.00
CHF 1'608.90 (7%)
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Details

SASRIN™ (=Super Acid Sensitive ResIN) was developed in our own laboratories especially for Fmoc solid phase synthesis (EP 0 292 729, US 4,831,084 and US 4,914,151). Its high acid lability enables the cleavage and isolation of the protected peptide fragment.
Beside SPPS SASRIN™ has been used in several organic reactions like the synthesis of 4-aryl substituted β-lactams employing Suzuki and Heck couplings, the synthesis of β-sultams, quinazoline-2,4-diones, pyridines and pyrido[2,3-d]pyrimidines and the generation of secondary alkylamines by borane reduction. S.S.Rahman et al. reported on the FT-IR and Raman spectroscopic monitoring of reactions on a single SASRIN™ bead and C.L.Brummel et al. on the evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries.
For a review on the manifold applications of our SASRIN™ resin, including many useful procedures, please ask for our SASRIN™ brochure.
Bachem offers a large variety of Fmoc-amino acids linked to SASRIN™ resin. See also D-2440.
Item Number 4012712
Synonyms 3-CH₃O-4-HOCH₂-Ph-O-CH₂-Ph-polymer
Substitution 0.80-1.20 mmol/g
CAS Registry Number [124760-64-1]
Storage Conditions +5 ± 3 °C

Product citations

M.Mergler et al., Chimia, 53, 29 (1999)
S.S.Rahmann et al., J. Org. Chem., 63, 6196 (1998)
M.F.Gordeev et al., Tetrahedron Lett., 38, 1729 (1997)
B.Ruhland et al., J. Org. Chem., 62, 7820 (1997)
M.Mergler et al., Peptides, Chemistry and Biology, Proceedings of the 10th American Peptide Symposium, St. Louis, p. 259, G.R.Marshall, ed., Escom, Leiden, (1988)
M.Mergler et al., Tetrahedron Lett., 29, 4009 (1988)
M.Mergler et al., Tetrahedron Lett., 29, 4005 (1988)