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Availability: In stock

Wang resin (200-400 mesh, 0.80-1.20 mmol/g)
4-Alkoxybenzyl alcohol resin

D-1250

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
D-1250.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 72.00
CHF 66.96 (7%)
D-1250.0025 25 g Ships within 3-5 business days  
CHF 247.00
CHF 229.71 (7%)
D-1250.0100 100 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 752.00
CHF 699.36 (7%)
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Details

The Wang support, p-benzyloxybenzyl alcohol resin, is the most widely used resin for attaching carboxylic acids for further functionalization. Cleavage conditions for the ester anchor involve concentrated TFA or TFA/CH₂Cl₂ to provide carboxylic acids or cyclization-cleavage under acidic or basic conditions. Release of an amide function by treatment with an amine in the presence of a Lewis acid was also reported. Wang resin was used to add vinyl and iodobenzoic acids via carbodiimide coupling and the products subjected to Heck conditions with alkenes or with alkynes or to Suzuki coupling with boron reagents. The Ugi multicomponent condensation reaction was conducted on Wang resin with the carboxylic acid, amine or isonitrile as the anchored functional group. Solid-phase lactam syntheses were also achieved by reaction of the resin-bound isonitrile with an amine and an ω-keto-acid as well as other synthetic transformations such as the Biginelli reaction and construction of heterocycles such as quinolones, imidazoles, hydantoins, and 1,4-benzodiazepine-2,5-diones. On a Wang resin primary, secondary, and tertiary alcohols have been converted to 4-methoxybenzyl ethers. As well as anchoring carboxylic acids to Wang resin, phenols were attached under Mitsunobu conditions, subjected to further transformations and cleaved under acidic conditions.
Item Number 4003214
Synonyms Wang resin, 4-Benzyloxybenzyl alcohol resin, 4-HOCH₂-Ph-O-CH₂-Ph-polymer, p-Alkoxybenzyl alcohol resin
Substitution 0.80 - 1.20 mmol/g
Storage Conditions RT