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Availability: In stock

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

C-3900

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
C-3900.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 155.00
CHF 144.15 (7%)
C-3900.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 618.00
CHF 574.74 (7%)
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Details

Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.
Item Number 4026408
Synonyms PSI, Proteasome Inhibitor I, Z-Ile-Glu(OtBu)-Ala-L-leucinal
Molecular Formula C₃₂H₅₀N₄O₈
Relative Molecular Mass 618.77
CAS Registry Number [158442-41-2]
Source Synthetic
Storage Conditions -20 ± 5 °C

C-3900

Enzyme Substrates Inhibitors
Multicatalytic Endopeptidase Complex    
Proteasome Endopeptidase Complex