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Availability: In stock

Fmoc-Glu-allyl ester

B-2720

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
B-2720.0001 1 g Ships within 3-5 business days  
CHF 84.00
CHF 78.12 (7%)
B-2720.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 315.00
CHF 292.95 (7%)
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Details

α-Allyl esters are of special interest, because they are a useful tool for the on-resin synthesis of head-to-tail cyclic peptides, side-chain lactam peptides, glyco- and sulfo-peptides, and branched peptides. Allyl esters are cleaved quantitatively under mild conditions using Pd(0). These conditions are compatible with Fmoc- and Boc-SPPS. Fmoc-Glu-OAll is a versatile educt for the synthesis of N-modified glutamines.
Due to the lack of steric hindrance of the allyl group, prolonged treatment with harsher Fmoc cleavage agents or even piperidine may induce side-reactions as glutarimide formation, as observed by Zhu and Marchant.
Item Number 4026433
Synonyms Fmoc-Glu-OAll
Molecular Formula C₂₃H₂₃NO₆
Relative Molecular Mass 409.44
CAS Registry Number [144120-54-7]
Storage Conditions -20 ± 5 °C

Bachem product citations

T.Nuijens et al., Synthesis, 2009, 809 (2009)

Product citations

F.Albericio et al., Peptides 1992, Proceedings of the 22nd European Peptide Symposium, Interlaken, Switzerland, p. 191, C.H.Schneider and A.N.Eberle, eds., Escom, Leiden, (1993)