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Availability: In stock

Fmoc-Glu-allyl ester

B-2720

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
B-2720.0001 1 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 82.00
CHF 76.26 (7%)
B-2720.0005 5 g Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 309.00
CHF 287.37 (7%)
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Details

α-Allyl esters are of special interest, because they are a useful tool for the on-resin synthesis of head-to-tail cyclic peptides, side-chain lactam peptides, glyco- and sulfo-peptides, and branched peptides. Allyl esters are cleaved quantitatively under mild conditions using Pd(0). These conditions are compatible with Fmoc- and Boc-SPPS. Fmoc-Glu-OAll is a versatile educt for the synthesis of N-modified glutamines.
Due to the lack of steric hindrance of the allyl group, prolonged treatment with harsher Fmoc cleavage agents or even piperidine may induce side-reactions as glutarimide formation, as observed by Zhu and Marchant.
Item Number 4026433
Synonyms Fmoc-Glu-OAll
Molecular Formula C₂₃H₂₃NO₆
Relative Molecular Mass 409.44
CAS Registry Number [144120-54-7]
Storage Conditions -20 ± 5 °C

Product citations

F.Albericio et al., Peptides 1992, Proceedings of the 22nd European Peptide Symposium, Interlaken, Switzerland, p. 191, C.H.Schneider and A.N.Eberle, eds., Escom, Leiden, (1993)